Lakatos L, Kövér B, Vekerdy S, Dvorácsek E
Acta Paediatr Acad Sci Hung. 1976;17(2):93-102.
A total 330 newborns suffering from haemolytic disease of the newborn and hyperbilirubinaemia was treated with D-penicillamine. The therapy resulted in a significant decrease in the frequency of exchange transfusions and of high serum bilirubin levels among preterm and fullterm babies with or without sensitization. Concerning the drug's mechanism of action, reduction of the bilirubin level is achieved by means of the copper stored in the liver. The intravenous route is suggested for application of the drug. In preterm infants D-penicillamine treatment proved more effective than phototherapy.
共有330例患有新生儿溶血病和高胆红素血症的新生儿接受了青霉胺治疗。该疗法使有或无致敏的早产和足月婴儿的换血频率和高血清胆红素水平显著降低。关于该药物的作用机制，胆红素水平的降低是通过肝脏中储存的铜来实现的。建议采用静脉途径给药。在早产儿中，青霉胺治疗被证明比光疗更有效。
