Romagnoli C, Muzii U, Maggio L, De Carolis M P, Zecca E, Zuppa A A, Tortorolo G
Divisione Neonatologica Università Cattolica del Sacro Cuore, Roma, Italia.
Pediatr Med Chir. 1987 Mar-Apr;9(2):191-5.
The authors studied the effects of different kinds of phototherapy in 186 newborns with a gestational age less than 33 weeks and weighing less than 2500 g. A control group of 60 infants was compared with a group of 31 infants submitted to photoprophylaxis, a group of 54 infants treated with day light, and a group of 41 infants treated with day light + special blue light. As far as the serum bilirubin variations in the first week, the maximum levels attained and the number of exchange transfusions are concerned, phototherapy always proved effective in reducing potentially neurotoxic serum bilirubin concentrations. Among the infants subjected to treatment, those treated with the day light showed a significant smaller decrease of serum bilirubin compared to those treated with the day light + special blue light, even if levels above 15 mg/dl were found in a similar percentage. Only 3.2% of the babies treated with photoprophylaxis showed serum bilirubin values above 15 mg/dl. The authors conclude that prophylaxis seems to be preferable to other phototherapeutic schedules used in the treatment of hyperbilirubinemia in low gestational age infants.
作者研究了不同类型光疗对186例孕周小于33周、体重小于2500克的新生儿的影响。将60例婴儿的对照组与31例接受预防性光疗的婴儿组、54例接受日光治疗的婴儿组以及41例接受日光+特殊蓝光治疗的婴儿组进行了比较。就第一周的血清胆红素变化、达到的最高水平以及换血次数而言，光疗始终被证明能有效降低潜在神经毒性的血清胆红素浓度。在接受治疗的婴儿中，接受日光治疗的婴儿血清胆红素下降幅度明显小于接受日光+特殊蓝光治疗的婴儿，即便胆红素水平高于15mg/dl的婴儿比例相似。接受预防性光疗的婴儿中只有3.2%的血清胆红素值高于15mg/dl。作者得出结论，对于低孕周婴儿高胆红素血症的治疗，预防性光疗似乎优于其他光疗方案。
