Ben-Ari Y, Lagowska J
C R Acad Hebd Seances Acad Sci D. 1978 Oct 9;287(8):813-6.
Intra-amygdaloid unilateral application of low doses of kainic acid rapidly elicits, in both chronic and acute conditions, secondarily generalized convulsive seizures which often culminate in fatal true status epilepticus unless appropriate anti-epileptic drugs are provided. Spontaneous recurrent seizures are observed for several hours starting approximately 10 min. after the application of kainic acid. In addition to the primary degeneration in the amygdaloid complex, a secondary cell loss is seen in CA3 area of the dorsal hippocampus. It is suggested that this procedure may constitute a particularly suitable model for the study of true focalized status epilepticus.
在慢性和急性条件下，向杏仁核单侧低剂量注射海藻酸均会迅速引发继发性全身性惊厥发作，若不给予适当的抗癫痫药物，这些发作往往会发展为致命的真正癫痫持续状态。在注射海藻酸后约10分钟开始，会观察到自发反复性发作持续数小时。除了杏仁核复合体的原发性变性外，在背侧海马体的CA3区还可见继发性细胞丢失。有人认为，该程序可能构成研究真正局灶性癫痫持续状态的特别合适的模型。
