Rusina Evgeniia, Bernard Christophe, Williamson Adam
Institute de Neurosciences des Systèmes, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1106, Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France.
Institute de Neurosciences des Systèmes, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1106, Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France
eNeuro. 2021 Apr 9;8(2). doi: 10.1523/ENEURO.0337-20.2021. Print 2021 Mar-Apr.
Experimental models of epilepsy are useful to identify potential mechanisms of epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) model is one of the most commonly used. Several modes of administration of KA exist, each producing different effects in a strain-, species-, gender-, and age-dependent manner. In this review, we discuss the advantages and limitations of the various forms of KA administration (systemic, intrahippocampal, and intranasal), as well as the histologic, electrophysiological, and behavioral outcomes in different strains and species. We attempt a personal perspective and discuss areas where work is needed. The diversity of KA models and their outcomes offers researchers a rich palette of phenotypes, which may be relevant to specific traits found in patients with temporal lobe epilepsy.
癫痫实验模型有助于识别癫痫发生、发作产生、合并症及治疗效果的潜在机制。海藻酸（KA）模型是最常用的模型之一。KA有多种给药方式，每种方式在不同品系、物种、性别和年龄中产生不同的效果。在本综述中，我们讨论了KA各种给药形式（全身给药、海马内给药和鼻内给药）的优缺点，以及不同品系和物种中的组织学、电生理学和行为学结果。我们尝试从个人角度进行探讨，并讨论需要开展研究的领域。KA模型及其结果的多样性为研究人员提供了丰富的表型选择，这些表型可能与颞叶癫痫患者的特定特征相关。
