Navajas A, Astigarraga I, Fernández-Teijeiro A, Aga M, Redondo M L, Roig A, Corral J
Unidad de Oncología Pediátrica, Hospital de Cruces, Baracaldo, Vizcaya.
Enferm Infecc Microbiol Clin. 1999 Apr;17(4):162-5.
Varicella vaccine has shown its efficacy to prevent the disease and complications in healthy and immunodeficient children. In this article the authors evaluate the immunologic status of acute lymphoblastic leukaemia at diagnosis and at follow up and the development of chickenpox and/or herpes zoster. Children with negative serology and continuous complete remission of acute lymphoblastic leukaemia for one year were vaccinated. Of 71 children diagnosed of acute lymphoblastic leukaemia from 1983 to 1996, 25 received the vaccine and seroconversion was obtained in 76% after one dose and 92% after the second dose. Vaccine tolerance was adequate. The incidence of herpes zoster infection was decreased in vaccinated children during chemotherapy compared to the wild-virus infected ones. Nowadays that vaccine for healthy children is recommended, we consider a priority to protect from chickenpox the children affected by leukaemia that are in continuous complete remission of the disease.
水痘疫苗已显示出其在预防健康儿童和免疫缺陷儿童患病及并发症方面的功效。在本文中,作者评估了急性淋巴细胞白血病患儿在诊断时和随访时的免疫状态以及水痘和/或带状疱疹的发生情况。对血清学阴性且急性淋巴细胞白血病持续完全缓解一年的儿童进行了疫苗接种。在1983年至1996年诊断为急性淋巴细胞白血病的71名儿童中,25名接种了疫苗,一剂后血清转化率为76%,第二剂后为92%。疫苗耐受性良好。与野生病毒感染的儿童相比,接种疫苗的儿童在化疗期间带状疱疹感染的发生率有所降低。鉴于现在推荐为健康儿童接种疫苗,我们认为优先保护处于疾病持续完全缓解状态的白血病患儿免受水痘感染。