Lou J, Tan A M, Tan C K
Department of Paediatrics, Tan Tock Seng Hospital, Singapore.
Singapore Med J. 1996 Dec;37(6):607-10.
Varicella is a common benign childhood illness. Rarely, serious complications arise. Immunocompromised patients usually suffer a more serious form of the illness. It is therefore prudent to prevent the infection in this group of patients. Varicella vaccination has been proven by several workers to be effective in both healthy children and adults as well as in leukaemic children. As the vaccine had not been licensed for sale in Singapore, we could only import 10 doses of the vaccine under special license. This was given to 8 leukaemic children. Of this, 5 seroconverted after the first dose. Two patients had the benefit of a repeat vaccination 3 months later. Both subsequently seroconverted. Two of the patients died from a relapse of the illness, a year and 2 years after the vaccination. None of the patients developed any side effects of fever and pain or varicella or zoster after the immunisation even though there was close contact with chicken pox. Although the study sample was small, it appeared that the vaccine was safe and efficacious in leukaemic children, especially after a 2-dose injection.
水痘是一种常见的儿童良性疾病。严重并发症很少出现。免疫功能低下的患者通常会患更严重的疾病形式。因此，预防这组患者感染是明智的。几位研究人员已证明水痘疫苗对健康儿童和成人以及白血病儿童均有效。由于该疫苗在新加坡未获销售许可，我们只能在特别许可下进口10剂疫苗。这10剂疫苗给了8名白血病儿童。其中，5名儿童在接种第一剂后血清转化。两名患者在3个月后受益于重复接种。两人随后均血清转化。两名患者在接种疫苗一年和两年后因疾病复发死亡。尽管与水痘患者密切接触，但没有患者在免疫接种后出现发热、疼痛、水痘或带状疱疹等任何副作用。虽然研究样本较小，但疫苗似乎对白血病儿童是安全有效的，尤其是在接种两剂后。
