苯妥英过敏引起的可逆性肾衰竭和肌炎。

Reversible renal failure and myositis caused by phenytoin hypersensitivity.

作者信息

Michael J R, Mitch W E

出版信息

JAMA. 1976 Dec 13;236(24):2773-5.

Abstract

A 38-year old woman receiving phenytoin (diphenylhydantoin) noticed maculopapular erythema as the first manifestation of a syndrome that included acute renal failure and myositis in addition to fever, lymphadenopathy, exfoliative dermatitis, and hepatitis. Prednisolone sodium phosphate therapy resulted in resolution of this hypersensitivity reaction, and she recovered from renal insufficiency. The occurrence of renal failure and myositis in the spectrum of phenytoin hypersensitivity reactions is discussed, and the importance of a morbilliform rash in a patient receiving phenytoin is emphasized.

摘要

一名正在服用苯妥英钠（二苯乙内酰脲）的38岁女性出现斑丘疹性红斑，这是一种综合征的首发表现，该综合征除发热、淋巴结病、剥脱性皮炎和肝炎外，还包括急性肾衰竭和肌炎。磷酸泼尼松龙钠治疗使这种超敏反应消退，她从肾功能不全中康复。文中讨论了苯妥英钠超敏反应谱中出现肾衰竭和肌炎的情况，并强调了服用苯妥英钠患者中麻疹样皮疹的重要性。