肌病与对苯妥英钠的超敏反应。
Myopathy and hypersensitivity to phenytoin.
作者信息
Harney J, Glasberg M R
出版信息
Neurology. 1983 Jun;33(6):790-1. doi: 10.1212/wnl.33.6.790.
PMID:6682525
Abstract
A 19-year-old man with a generalized seizure disorder was treated with phenytoin. A hypersensitivity reaction was marked by hepatitis, severe myalgia, proximal arm weakness, and high serum creatine kinase. Biopsy was diagnostic of myopathy. Patients demonstrating abnormalities of immune responsiveness may best be managed by use of an alternative anticonvulsant.
摘要
一名患有全身性癫痫障碍的19岁男性接受了苯妥英治疗。超敏反应表现为肝炎、严重肌痛、近端手臂无力和血清肌酸激酶升高。活检诊断为肌病。对于表现出免疫反应异常的患者，使用替代抗惊厥药物可能是最佳治疗方法。
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