Scuteri A, Di Bernardo M G, De Propris A M, Marigliano V
Cattedra Gerontologia e Geriatria, Universita La Sapienza, Rome, Italy.
J Am Geriatr Soc. 1999 Jun;47(6):727-9. doi: 10.1111/j.1532-5415.1999.tb01598.x.
To evaluate the effects of hyperinsulinemia on left ventricular (LV) structure and function in older hypertensive subjects
Thirty-seven hypertensive subjects (17 men/20 women) aged 50 to 80, were studied. LV mass were evaluated echocardiographically according to the Penn convention. A 75-g oral glucose tolerance test (OGTT) was performed after overnight fasting, and both blood glucose and insulin concentrations were assayed at 0, 30, 60, 90, 120, and 180 minutes. Comparison between groups was performed by analysis of variance. A P value of .05 was considered statistically significant.
When the hypertensive patients were divided into two groups according to the median value of 2-hour post-loading plasma insulin, there was no difference in blood pressure levels between the groups. However, hyperinsulinemic hypertensive subjects had an increased LV mass (P < .05), mean wall thickness, and interventricular septum thickness (P < .05 for both parameters) and had better systolic function-ejection and shortening fractions (P < .0001 for both indices).
Hyperinsulinemia may be associated with increased left ventricular mass and with a better systolic performance in older hypertensive subjects.
评估高胰岛素血症对老年高血压患者左心室（LV）结构和功能的影响。
研究了37名年龄在50至80岁之间的高血压患者（17名男性/20名女性）。根据宾夕法尼亚公约通过超声心动图评估左心室质量。在过夜禁食后进行75克口服葡萄糖耐量试验（OGTT），并在0、30、60、90、120和180分钟时测定血糖和胰岛素浓度。通过方差分析进行组间比较。P值<.05被认为具有统计学意义。
当根据负荷后2小时血浆胰岛素的中值将高血压患者分为两组时，两组之间的血压水平没有差异。然而，高胰岛素血症高血压患者的左心室质量增加（P<.05），平均壁厚度和室间隔厚度增加（两个参数均P<.05），并且具有更好的收缩功能——射血分数和缩短分数（两个指标均P<.0001）。
高胰岛素血症可能与老年高血压患者左心室质量增加和更好的收缩性能有关。
