大肠杆菌中针对有毒亲电试剂的保护机制。

Protective mechanisms against toxic electrophiles in Escherischia coli.

作者信息

Ferguson G P

机构信息

Dept of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK AB25 2ZD.

出版信息

Trends Microbiol. 1999 Jun;7(6):242-7. doi: 10.1016/s0966-842x(99)01510-3.

DOI:10.1016/s0966-842x(99)01510-3

PMID:10366861

Abstract

Escherichia coli are exposed to toxic electrophiles from both endogenous and exogenous sources. To survive, E. coli have developed novel protective mechanisms that appear unique to bacteria. In the absence of one of these mechanisms, electrophiles induce rapid killing. Hence it appears that electrophile-protective mechanisms represent novel targets for antibacterial drug research.

摘要

大肠杆菌会接触到来自内源性和外源性的有毒亲电试剂。为了生存，大肠杆菌已经发展出了一些新的保护机制，这些机制似乎是细菌所特有的。如果缺少其中一种机制，亲电试剂会导致细菌迅速死亡。因此，亲电试剂保护机制似乎代表了抗菌药物研究的新靶点。