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暴露于碘乙酸盐和氯二硝基苯的大肠杆菌细胞的存活与谷胱甘肽门控的钾离子外流系统KefB和KefC无关。

Survival of Escherichia coli cells exposed to iodoacetate and chlorodinitrobenzene is independent of the glutathione-gated K+ efflux systems KefB and KefC.

作者信息

Ness L S, Ferguson G P, Nikolaev Y, Booth I R

机构信息

Department of Molecular and Cell Biology, University of Aberdeen, Foresterhill, United Kingdom.

出版信息

Appl Environ Microbiol. 1997 Oct;63(10):4083-6. doi: 10.1128/aem.63.10.4083-4086.1997.

DOI:10.1128/aem.63.10.4083-4086.1997
PMID:9327573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC168720/
Abstract

The KefB and KefC systems of Escherichia coli cells are activated by iodoacetate (IOA) and chlorodinitrobenzene (CDNB), leading to a rapid drop in the intracellular pH. However, survival of exposure to IOA or CDNB was found to be essentially independent of KefB and KefC activation. No correlation was found between the toxicity of the compound and its ability to elicit protective acidification via activation of KefB and KefC.

摘要

大肠杆菌细胞的KefB和KefC系统可被碘乙酸盐（IOA）和氯二硝基苯（CDNB）激活，导致细胞内pH值迅速下降。然而，发现暴露于IOA或CDNB后的存活率基本上与KefB和KefC的激活无关。未发现该化合物的毒性与其通过激活KefB和KefC引发保护性酸化的能力之间存在相关性。

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本文引用的文献

1
Glutathione-s-transferase activity and metabolism of glutathione conjugates by rhizosphere bacteria.根际细菌的谷胱甘肽转移酶活性和谷胱甘肽缀合物的代谢。
Appl Environ Microbiol. 1995 Mar;61(3):1054-60. doi: 10.1128/aem.61.3.1054-1060.1995.
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Bacterial glutathione S-transferases: what are they good for?细菌谷胱甘肽S-转移酶：它们有什么作用？
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Survival during exposure to the electrophilic reagent N-ethylmaleimide in Escherichia coli: role of KefB and KefC potassium channels.大肠杆菌暴露于亲电试剂N-乙基马来酰亚胺时的存活情况：KefB和KefC钾通道的作用
J Bacteriol. 1997 Feb;179(4):1007-12. doi: 10.1128/jb.179.4.1007-1012.1997.
4
The activity of the high-affinity K+ uptake system Kdp sensitizes cells of Escherichia coli to methylglyoxal.高亲和力钾离子摄取系统Kdp的活性使大肠杆菌细胞对甲基乙二醛敏感。
J Bacteriol. 1996 Jul;178(13):3957-61. doi: 10.1128/jb.178.13.3957-3961.1996.
5
Potassium channel activation by glutathione-S-conjugates in Escherichia coli: protection against methylglyoxal is mediated by cytoplasmic acidification.大肠杆菌中谷胱甘肽-S-共轭物对钾通道的激活：对甲基乙二醛的保护作用由细胞质酸化介导。
Mol Microbiol. 1995 Sep;17(6):1025-33. doi: 10.1111/j.1365-2958.1995.mmi_17061025.x.
6
Activation of potassium channels during metabolite detoxification in Escherichia coli.大肠杆菌代谢物解毒过程中钾通道的激活。
Mol Microbiol. 1993 Sep;9(6):1297-303. doi: 10.1111/j.1365-2958.1993.tb01259.x.
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Mutagenicity of 1-fluoro-2,4-dinitrobenzene is affected by bacterial glutathione.
Mutat Res. 1980 Apr;70(2):173-8. doi: 10.1016/0027-5107(80)90157-8.
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Osmotic control of kdp operon expression in Escherichia coli.大肠杆菌中kdp操纵子表达的渗透调控
Proc Natl Acad Sci U S A. 1981 Jan;78(1):464-8. doi: 10.1073/pnas.78.1.464.
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The relationship between intracellular pH, the pH gradient and potassium transport in Escherichia coli.大肠杆菌中细胞内pH值、pH梯度与钾离子转运之间的关系。
Biochem J. 1983 Dec 15;216(3):709-16. doi: 10.1042/bj2160709.
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