Rasina L N, Chupakhin O N
Institute of Organic Synthesis, Ural Branch Russian Academy of Sciences, Ekaterinburg.
Radiats Biol Radioecol. 1999 Mar-Jun;39(2-3):223-6.
Perspective chemical classes of prophylactic radioprotecting compounds were found from analysis of proper experimental data. Preparations effective in a wide range of radiation doses of various intensity were synthesized. Their activity are due to combination of antiradiation and many other pharmacological properties. During acute radiation these preparations protect stem cells pul of critical tissues but under prolonged radiation they normalize the hematological, immune and lipid peroxide oxidation systems. There is no strong correlation between radioprotection and increasing of functional reserve of organism.
通过对适当实验数据的分析，发现了预防性辐射防护化合物的透视化学类别。合成了在各种强度的广泛辐射剂量下有效的制剂。它们的活性归因于抗辐射和许多其他药理特性的结合。在急性辐射期间，这些制剂可保护关键组织的干细胞群，但在长期辐射下，它们可使血液学、免疫和脂质过氧化系统正常化。辐射防护与机体功能储备增加之间没有很强的相关性。
