Kalinina E V, Novichkova M D, Chirkova E M, Koppel' M A, Komissarova I A
Medical Research and Production Complex Biotics, Moscow.
Radiats Biol Radioecol. 1999 Mar-Jun;39(2-3):272-6.
Original MP-33 metabolic drug has inductive action on intracellular levels of glutathione (GSH) and GSH-related enzymes (glutathione peroxidase-GPx, glutathione S-transferase-GST) of animals and human (liver, heart, erythrocytes). Treatment of Wistar male rats with MP-33 per os (6 mg/kg) 30 min before gamma-irradiation with a dose of 7 Gy results in 35% survival and increasing of mean life. In "mother-foetus" system the induction of intracellular level of GSH, GST and GPx by MP-33 leads to enhancement of foetus radioresistance. In contrast to MP-33 us of GSH (6 and 100 mg/kg) is not effective. Perspective of MP-33 us in relation to radioecological crisis is discussed.
原始的MP - 33代谢药物对动物和人类（肝脏、心脏、红细胞）细胞内谷胱甘肽（GSH）水平及GSH相关酶（谷胱甘肽过氧化物酶 - GPx、谷胱甘肽S - 转移酶 - GST）具有诱导作用。在以7 Gy剂量进行γ射线照射前30分钟，经口给Wistar雄性大鼠服用MP - 33（6毫克/千克），可使存活率达到35%并延长平均寿命。在“母 - 胎”系统中，MP - 33对细胞内GSH、GST和GPx水平的诱导作用可增强胎儿的辐射抗性。与MP - 33相比，使用GSH（6和100毫克/千克）无效。讨论了MP - 33在应对放射生态危机方面的前景。
