Webster G K, Bell R G
Chemsultants, Ltd., Ozona, FL 34660, USA.
J AOAC Int. 1999 May-Jun;82(3):620-4.
An efficient method for gas chromatographic analysis of fosfomycin in plasma was developed for preliminary investigations of the bioavailability in poultry of 3 commercial complexes of fosfomycin: a levorotatory Ca(-) salt, a racemic Ca(+/-) salt, and a tromethamine (THAM) salt. The method was used to determine whether the less expensive racemic mixture would provide equivalent levels of fosfomycin in blood as the pure Ca(-) form and the THAM salt. The THAM salt, a more expensive product to market, was thought to have the greatest bioavailability. The assay is selective, sensitive, and applicable to pharmacokinetic analysis.
开发了一种用于血浆中磷霉素气相色谱分析的高效方法，以初步研究3种市售磷霉素复合物在家禽体内的生物利用度：左旋钙盐、消旋钙盐和三甲胺（THAM）盐。该方法用于确定价格较低的消旋混合物在血液中提供的磷霉素水平是否与纯钙（-）形式和THAM盐相当。THAM盐作为一种上市价格更高的产品，被认为具有最大的生物利用度。该测定具有选择性、灵敏性，适用于药代动力学分析。
