Dessalles M C, Levieux J, Souleau M, Mahuzier G
Pathol Biol (Paris). 1987 Feb;35(2):200-4.
A method in gas chromatography is proposed to determine fosfomycin in biological and bacterial or cellular culture medium. This technique is carried out on capillary column OV 17-01 after "Flash Methylation" with a thermionic detector. The detection limit is about 1 microgram per millilitre of serum for a trial assay of 100 microliters. His characteristics have been furthered. The treatment by antibiotics generally associated with fosfomycin don't cause any chromatographic interference for plasmatic assays.
提出了一种气相色谱法来测定生物及细菌或细胞培养基中的磷霉素。该技术在经过“快速甲基化”后，于毛细管柱OV 17 - 01上采用热离子检测器进行。对于100微升的试验测定，血清中的检测限约为每毫升1微克。其特性得到了进一步研究。通常与磷霉素联合使用的抗生素处理不会对血浆测定造成任何色谱干扰。
