Hou C C, Wu S C, Wu S C, Chen T W, Yang W C, Ng Y Y
Department of Medicine, Veterans General Hospital-Taipei, Taiwan, ROC.
Zhonghua Yi Xue Za Zhi (Taipei). 1999 Apr;62(4):189-94.
Serum transferrin receptor (sTfR) concentration has been recognized as a reliable laboratory indicator of iron deficiency in recent years. But its response to iron supplementation has not been investigated.
We evaluated the sTfR concentrations in 15 patients diagnosed with iron-deficiency anemia, in 30 patients receiving maintenance hemodialysis (HD) with iron repletion and in 31 healthy controls. The serial changes of sTfR concentration and their correlation with serum ferritin in patients with iron deficiency under iron repletion were also examined in three patients.
In patients with iron-deficiency anemia, the sTfR concentration was 5.6 +/- 2.4 mg/ml, significantly higher than that in the control group (1.8 +/- 0.4 mg/ml) and patients receiving maintenance HD with iron repletion (1.7 +/- 0.5 mg/ml). The three patients with iron-deficiency anemia who received eight to 16 weeks of iron supplementation showed steady and significant decreases in sTfR concentration and significant increases in serum ferritin and transferrin saturation. However, the decreases in sTfR concentration did not occur immediately, as did the increases in serum ferritin and transferrin saturation, following iron repletion. There was a four-week delayed response in the decrease of sTfR concentrations as measured against serum ferritin and transferrin saturation.
sTfR concentration may not be as effective as an early index of iron repletion compared with serum ferritin and transferrin saturation.
近年来，血清转铁蛋白受体（sTfR）浓度已被公认为缺铁的可靠实验室指标。但其对铁补充的反应尚未得到研究。
我们评估了15例诊断为缺铁性贫血的患者、30例接受铁补充维持性血液透析（HD）的患者以及31名健康对照者的sTfR浓度。还对3例缺铁患者在补充铁剂后sTfR浓度的系列变化及其与血清铁蛋白的相关性进行了检查。
缺铁性贫血患者的sTfR浓度为5.6±2.4mg/ml，显著高于对照组（1.8±0.4mg/ml）和接受铁补充维持性HD的患者（1.7±0.5mg/ml）。3例接受8至16周铁补充的缺铁性贫血患者sTfR浓度稳步且显著下降，血清铁蛋白和转铁蛋白饱和度显著增加。然而，与血清铁蛋白和转铁蛋白饱和度在补充铁剂后立即升高不同，sTfR浓度的下降并未立即发生。与血清铁蛋白和转铁蛋白饱和度相比
