Tseng G Y, Lin H J, Lin H Y, Perng C L, Lee F Y, Lo W C, Tsay S H, Li A F, Chang F Y, Lee S D
Department of Medicine, Veterans General Hospital-Taipei, Taiwan, ROC.
Zhonghua Yi Xue Za Zhi (Taipei). 1999 Apr;62(4):217-22.
Controversy exists concerning the influence of Helicobacter pylori on gastric secretion. Hyper-, normo- and hyposecretion of gastric acid in normal subjects with H pylori infection have been reported, although there is no such report for Chinese subjects. The goal of this study was to identify the effect of H pylori on gastric secretion in normal Chinese subjects.
Twenty normal subjects with a normal upper gastrointestinal tract by endoscopy were recruited. H pylori status was assayed by a rapid urease test. Gastric secretion and gastrin release were also measured.
Among the subjects studied, nine were infected with H pylori. All enrolled subjects were males. Age and body weight were similar between both groups. No significant difference was found in basal acid output, maximal acid output, basal pepsin output or maximal pepsin output between the H pylori-positive group (median, 1.1 mmol/hour, 95% confidence interval 0.2-3.6 mmol/hour; 8.0, 3.0-18.3 mmol/hour; 0, -1.3-11.2 mmol/hour; and 4.1, -4.2-59.3 mmol/hour, respectively) and the H pylori-negative group (2.5, -1.3-11.3 mmol/hour; 12.2, 8.7-26.9 mmol/hour; 4.3, 1.8-13.5 mmol/hour; and 14.8, -5.7-73.0 mmol/hour, respectively). Serum basal gastrin and pepsinogen I concentration were 63.5, 50.0-78.6 pg/ml and 75.1, 50.6-89.8 ng/ml in the H pylori-positive group, and 65.9, 50.2-79.8 pg/ml and 79.1, 59.5-120.1 ng/ml in the H pylori-negative group (p > 0.05).
H pylori plays no role in the gastric secretion and gastrin release in normal Chinese subjects.
幽门螺杆菌对胃酸分泌的影响存在争议。已有报道称，幽门螺杆菌感染的正常受试者存在胃酸分泌过多、正常分泌和分泌过少的情况，不过尚无针对中国受试者的此类报道。本研究的目的是确定幽门螺杆菌对正常中国受试者胃酸分泌的影响。
招募了20名经内镜检查上消化道正常的正常受试者。通过快速尿素酶试验检测幽门螺杆菌感染状况。同时测量胃酸分泌和胃泌素释放情况。
在研究的受试者中，9人感染了幽门螺杆菌。所有入选受试者均为男性。两组之间的年龄和体重相似。幽门螺杆菌阳性组（中位数分别为1.1毫摩尔/小时，95%置信区间0.2 - 3.6毫摩尔/小时；8.0，3.0 - 18.3毫摩尔/小时；0， - 1.3 - 11.2毫摩尔/小时；以及4.1， - 4.2 - 59.3毫摩尔/小时）和幽门螺杆菌阴性组（分别为2.5， - 1.3 - 11.3毫摩尔/小时；12.2，8.7 - 26.9毫摩尔/小时；4.3，1.8 - 13.5毫摩尔/小时；以及14.8， - 5.7 - 73.0毫摩尔/小时）在基础酸排出量、最大酸排出量、基础胃蛋白酶排出量或最大胃蛋白酶排出量方面均未发现显著差异。幽门螺杆菌阳性组血清基础胃泌素和胃蛋白酶原I浓度分别为63.5，50.0 - 78.6皮克/毫升和75.1，50.6 - 89.8纳克/毫升，幽门螺杆菌阴性组分别为65.9，50.2 - 79.8皮克/毫升和79.1，59.5 - 120.1纳克/毫升（p > 0.05）。
幽门螺杆菌对正常中国受试者的胃酸分泌和胃泌素释放无影响。
