Suarez E C
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
Psychosom Med. 1999 May-Jun;61(3):273-9. doi: 10.1097/00006842-199905000-00004.
Recent evidence suggests that naturally occurring low cholesterol concentrations (<4.14 mmol/liter) are associated with depression as well as poor psychological health. For the most part, these associations have been observed in men. The current study assessed the relation of naturally occurring low lipid and lipoprotein concentrations to trait measures of depression and anxiety in 121 healthy young adult women.
Fasting lipid samples were collected at the same time as health history. Trait depression and anxiety were assessed using the Neuroticism, Extraversion, Openness-Personality Inventory (NEO-PI) depression subscale and Spielberger's Trait Personality Inventory (STPI) anxiety subscale. Analyses were conducted using both univariate and multivariate procedures.
NEO depression was inversely associated with total cholesterol (p = .027), triglycerides (p = .012), and the ratio of total cholesterol to high-density lipoprotein cholesterol (p = .059). Similarly, STPI anxiety was inversely associated with total cholesterol (p = .002), low-density lipoprotein cholesterol (p = .016), triglycerides (p = .024), and ratio of total cholesterol to high-density lipoprotein cholesterol (p = .075). These associations were significant after adjustment for age, body mass index, physical activity, oral contraceptive use, and hostility. Neither depression nor anxiety was associated with high-density lipoprotein cholesterol. Univariate analyses indicated that women with low total cholesterol concentrations (<4.14 mmol/liter), relative to those with moderate to high cholesterol levels, were more likely to have higher scores on the NEO depression subscale (27 of 69 (39%) vs. 10 of 52 (19%)) and STPI anxiety subscale (24 of 69 (35%) vs. 11 of 52 (21%)).
In healthy young adult women, low lipid and lipoprotein concentrations are inversely associated with trait measures of depression and anxiety. These findings are independent of age, body mass index, physical activity, and other factors known to influence lipid concentrations.
近期证据表明，自然发生的低胆固醇浓度（<4.14 mmol/升）与抑郁症以及心理健康状况不佳有关。在很大程度上，这些关联在男性中已被观察到。本研究评估了121名健康年轻成年女性中自然发生的低血脂和脂蛋白浓度与抑郁和焦虑特质测量之间的关系。
在收集健康史的同时采集空腹血脂样本。使用神经质、外向性、开放性人格量表（NEO-PI）抑郁分量表和斯皮尔伯格特质人格量表（STPI）焦虑分量表评估特质抑郁和焦虑。采用单变量和多变量程序进行分析。
NEO抑郁与总胆固醇（p = 0.027）、甘油三酯（p = 0.012）以及总胆固醇与高密度脂蛋白胆固醇的比值（p = 0.059）呈负相关。同样，STPI焦虑与总胆固醇（p = 0.002）、低密度脂蛋白胆固醇（p = 0.016）、甘油三酯（p = 0.024）以及总胆固醇与高密度脂蛋白胆固醇的比值（p = 0.075）呈负相关。在对年龄、体重指数、身体活动、口服避孕药使用情况和敌意进行调整后，这些关联仍然显著。抑郁和焦虑均与高密度脂蛋白胆固醇无关。单变量分析表明，总胆固醇浓度低（<4.14 mmol/升）的女性相对于胆固醇水平中等至较高的女性，在NEO抑郁分量表上得分更高的可能性更大（69人中有27人（39%），而52人中有10人（19%）），在STPI焦虑分量表上得分更高的可能性也更大（69人中有24人（35%），而52人中有11人（21%））。
在健康年轻成年女性中，低血脂和脂蛋白浓度与抑郁和焦虑特质测量呈负相关。这些发现独立于年龄、体重指数、身体活动以及其他已知影响血脂浓度的因素。
