Exton M S, Bindert A, Krüger T, Scheller F, Hartmann U, Schedlowski M
Department of Medical Psychology, University Clinic Essen, Germany.
Psychosom Med. 1999 May-Jun;61(3):280-9. doi: 10.1097/00006842-199905000-00005.
The present study investigated the cardiovascular, genital, and endocrine changes in women after masturbation-induced orgasm because the neuroendocrine response to sexual arousal in humans is equivocal.
Healthy women (N = 10) completed an experimental session, in which a documentary film was observed for 20 minutes, followed by a pornographic film for 20 minutes, and another documentary for an additional 20 minutes. Subjects also participated in a control session, in which participants watched a documentary film for 60 minutes. After subjects had watched the pornographic film for 10 minutes in the experimental session, they were asked to masturbate until orgasm. Cardiovascular (heart rate and blood pressure) and genital (vaginal pulse amplitude) parameters were monitored continuously throughout testing. Furthermore, blood was drawn continuously for analysis of plasma concentrations of adrenaline, noradrenaline, cortisol, prolactin, luteinizing hormone (LH), beta-endorphin, follicle-stimulating hormone (FSH), testosterone, progesterone, and estradiol.
Orgasm induced elevations in cardiovascular parameters and levels of plasma adrenaline and noradrenaline. Plasma prolactin substantially increased after orgasm, remained elevated over the remainder of the session, and was still raised 60 minutes after sexual arousal. In addition, sexual arousal also produced small increases in plasma LH and testosterone concentrations. In contrast, plasma concentrations of cortisol, FSH, beta-endorphin, progesterone, and estradiol were unaffected by orgasm.
Sexual arousal and orgasm produce a distinct pattern of neuroendocrine alterations in women, primarily inducing a long-lasting elevation in plasma prolactin concentrations. These results concur with those observed in men, suggesting that prolactin is an endocrine marker of sexual arousal and orgasm.
由于人类对性唤起的神经内分泌反应尚不明确，本研究调查了女性自慰诱导性高潮后的心血管、生殖器官及内分泌变化。
10名健康女性完成一个实验环节，其中先观看20分钟纪录片，接着观看20分钟色情影片，随后再观看20分钟另一部纪录片。受试者还参与了一个对照环节，即观看60分钟纪录片。在实验环节中，受试者观看色情影片10分钟后，被要求自慰直至达到性高潮。在整个测试过程中持续监测心血管参数（心率和血压）和生殖器官参数（阴道脉搏振幅）。此外，持续采集血液以分析血浆中肾上腺素、去甲肾上腺素、皮质醇、催乳素、促黄体生成素（LH）、β-内啡肽、促卵泡激素（FSH）、睾酮、孕酮和雌二醇的浓度。
性高潮导致心血管参数以及血浆肾上腺素和去甲肾上腺素水平升高。性高潮后血浆催乳素大幅增加，在该环节剩余时间内持续升高，且在性唤起后60分钟仍保持升高。此外，性唤起还使血浆LH和睾酮浓度略有增加。相比之下，血浆皮质醇、FSH、β-内啡肽、孕酮和雌二醇的浓度不受性高潮影响。
性唤起和性高潮在女性中产生了一种独特的神经内分泌变化模式，主要导致血浆催乳素浓度长期升高。这些结果与在男性中观察到的结果一致，表明催乳素是性唤起和性高潮的一种内分泌标志物。
