缓激肽、前列腺素E1、5-羟色胺、组胺及腺苷-5'-三磷酸对大鼠皮肤干性渗漏反应的相互作用

Interactions of bradykinin, prostaglandin E1, 5-hydroxytryptamine, histamine and adenosine-5'-triphosphate on the dry leakage response in rat skin.

作者信息

Chahl L A

出版信息

J Pharm Pharmacol. 1976 Oct;28(10):753-7. doi: 10.1111/j.2042-7158.1976.tb04041.x.

DOI:10.1111/j.2042-7158.1976.tb04041.x

Abstract

Dye leakage in rats produced by intracutaneous injections of irritants was quantitated using an azovan blue technique. Concentration-response lines were obtained for irritants alone and in presence of constant concentrations of other irritants. 5-Hydroxytryptamine (5-HT) (10-7M) potentiated histamine, bradykinin and prostaglandin E1 (PGE1) but inhibited adenosine-5'-triphosphate (ATP). Histamine (10-5M) potentiated bradykinin, PGE1 and ATP. Bradykinin (10-6M) potentiated PGE1 only, but PGE1 (10-6M) potentiated bradykinin, 5-HT and histamine. ATP (10-4M) potentiated 5-HT, histamine and PGE1. Release of ATP during stimulation of sensory nerves might explain enhanced neurogenic oedema observed in skin surrounding an area pretreated with compound 48/80.

摘要

采用偶氮蓝技术对大鼠皮内注射刺激物引起的染料渗漏进行定量。分别获得了单独刺激物以及在存在恒定浓度其他刺激物情况下的浓度-反应曲线。5-羟色胺（5-HT）（10⁻⁷M）增强组胺、缓激肽和前列腺素E1（PGE1）的作用，但抑制腺苷-5'-三磷酸（ATP）。组胺（10⁻⁵M）增强缓激肽、PGE1和ATP的作用。缓激肽（10⁻⁶M）仅增强PGE1的作用，但PGE1（10⁻⁶M）增强缓激肽、5-HT和组胺的作用。ATP（10⁻⁴M）增强5-HT、组胺和PGE1的作用。感觉神经刺激期间ATP的释放可能解释了在用48/80化合物预处理区域周围皮肤中观察到的神经源性水肿增强现象。