前列腺素、缓激肽、5-羟色胺和组胺对犬滑膜微循环相对作用的研究。
Studies on the relative effects of prostaglandins, bradykinin, 5-hydroxytryptamine and histamine on the synovial microcirculation in dogs.
作者信息
Dick W C, Grennan D M, Zeitlin I J
出版信息
Br J Pharmacol. 1976 Mar;56(3):313-6. doi: 10.1111/j.1476-5381.1976.tb07644.x.
Abstract
1 The relative effects of prostaglandins E1, E2, F1alpha, F2alpha, bradykinin, histamine and 5-hydroxytryptamine (5-HT) on the canine synovial microcirculation were investigated using the rate of clearance of radioactive xenon (133Xe) as an index of synovial perfusion. 2 All the compounds tested, except prostaglandin F1alpha, produced a vasodilator effect. The descending order of potency of the active compounds was (i) prostaglandin E1, (ii) prostaglandin E2 and bradykinin, (iii) histamine and 5-HT, (iv) prostaglandin F2alpha. The most potent compound tested, prostaglandin E1 produced an effect in nanogram amounts in each joint. 3 Prostaglandin F2alpha has been reported to have an anti-inflammatory action; however no evidence was found of antagonism of prostaglandin E1 by two dose levels of prostaglandin F2alpha. 4 Preliminary studies showed that threshold doses of prostaglandin E1 did not potentiate the vasodilator action of threshold or sub-threshold doses of bradykinin in the dog synovium.
摘要
- 以放射性氙（133Xe）的清除率作为滑膜灌注指标，研究了前列腺素E1、E2、F1α、F2α、缓激肽、组胺和5-羟色胺（5-HT）对犬滑膜微循环的相对作用。2. 除前列腺素F1α外，所有受试化合物均产生血管舒张作用。活性化合物的效力递减顺序为：（i）前列腺素E1，（ii）前列腺素E2和缓激肽，（iii）组胺和5-HT，（iv）前列腺素F2α。受试的最有效化合物前列腺素E1在每个关节中以纳克量产生作用。3. 据报道前列腺素F2α具有抗炎作用；然而，未发现两种剂量水平的前列腺素F2α对前列腺素E1有拮抗作用的证据。4. 初步研究表明，前列腺素E1的阈剂量不会增强犬滑膜中缓激肽阈剂量或亚阈剂量的血管舒张作用。
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