前列腺素D2在大鼠和人类皮肤中的炎症作用。
Inflammatory effects of prostaglandin D2 in rat and human skin.
作者信息
Flower R J, Harvey E A, Kingston W P
出版信息
Br J Pharmacol. 1976 Feb;56(2):229-33. doi: 10.1111/j.1476-5381.1976.tb07446.x.
Abstract
1 Intradermal injection of prostaglandin (PG) D1 and D2 in the human forearm produced a long-lasting dose-related erythema. When compared with prostaglandin E1 or E2 the order of potency for erythema production was PGE1 greater than PGE2 greater than PGD2 greater than PGD1. 2 In rat skin, prostaglandin D2 but not D1 caused an increase in vascular permeability as quantitated by the Evans blue method and the 125I-albumin extravasation technique. Prostaglandin E2 was 3-5 times more potent than prostaglandin D2. 3 Prostaglandin D2 (10 ng) potentiated the increase in vascular permeability in rat skin produced by histamine, but not that produced by bradykinin. 4 Prostaglandin D2 (10, 20 and 50 ng) did not elicit oedema or hyperalgesia in the rat paw oedema test, but potentiated carrageenan-induced oedema; hyperalgesia was potentiated by doses of 100 ng and above.
摘要
- 将前列腺素（PG）D1和D2皮内注射到人体前臂会产生持续时间较长的剂量相关性红斑。与前列腺素E1或E2相比，产生红斑的效力顺序为PGE1＞PGE2＞PGD2＞PGD1。2. 在大鼠皮肤中，通过伊文思蓝法和125I-白蛋白外渗技术定量显示，前列腺素D2而非D1会导致血管通透性增加。前列腺素E2的效力比前列腺素D2强3至5倍。3. 前列腺素D2（10纳克）可增强组胺引起的大鼠皮肤血管通透性增加，但对缓激肽引起的增加无增强作用。4. 在大鼠足爪水肿试验中，前列腺素D2（10、20和50纳克）不会引起水肿或痛觉过敏，但可增强角叉菜胶诱导的水肿；100纳克及以上剂量可增强痛觉过敏。
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本文引用的文献
1
Prostaglandin on cutaneous vasculature.前列腺素对皮肤血管系统的作用。
J Invest Dermatol. 1968 Oct;51(4):280-2.
2
Biosynthesis of 9-alpha,15-dihydroxy-11-ketoprost-13-enoic acid.9-α,15-二羟基-11-酮基前列腺-13-烯酸的生物合成
J Biol Chem. 1968 Aug 10;243(15):4104-8.
3
Recovery of prostaglandins in human cutaneous inflammation.人类皮肤炎症中前列腺素的恢复情况。
Br Med J. 1971 May 1;2(5756):258-60. doi: 10.1136/bmj.2.5756.258.
4
A hypertensive response to infusion of prostaglandin F 2 into the vertebral artery of the conscious dog.向清醒犬椎动脉内注入前列腺素F 2后出现的高血压反应。
Eur J Pharmacol. 1971 Oct;16(2):229-32. doi: 10.1016/0014-2999(71)90017-3.
5
Comparative pharmacological actions of bradykinin and related kinins of larger molecular weights.缓激肽及相关较大分子量激肽的比较药理作用
Biochem Pharmacol. 1971 Nov;20(11):2935-46. doi: 10.1016/0006-2952(71)90096-7.
6
Efflux of prostaglandins in lymph from scalded tissue.前列腺素从烫伤组织的淋巴液中流出。
Acta Physiol Scand. 1971 Apr;81(4):440-7. doi: 10.1111/j.1748-1716.1971.tb04921.x.
7
Isolation and properties of intermediates in prostaglandin biosynthesis.前列腺素生物合成中间体的分离与特性
Biochim Biophys Acta. 1973 Dec 20;326(3):448-61. doi: 10.1016/0005-2760(73)90145-8.
8
Distribution of prostaglandins in inflammatory exudate.前列腺素在炎性渗出物中的分布。
J Pathol. 1973 Nov;111(3):149-58. doi: 10.1002/path.1711110302.
9
Itch: role of prostaglandins.瘙痒：前列腺素的作用
Br Med J. 1973 Sep 22;3(5881):608-9. doi: 10.1136/bmj.3.5881.608.
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Increased synthesis of prostaglandins in the guinea pig following scalding injury.豚鼠烫伤后前列腺素合成增加。
Acta Physiol Scand. 1973 Feb;87(2):240-5. doi: 10.1111/j.1748-1716.1973.tb05386.x.
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