四磷酸腺苷对二磷酸腺苷诱导的血小板聚集的抑制作用。
Inhibition of ADP-induced platelet aggregation by adenosine tetraphosphate.
作者信息
Harrison M J, Brossmer R
出版信息
Thromb Haemost. 1976 Nov 30;36(2):388-91.
PMID:1036839
Abstract
In contrast to previous reports, highly purified adenosine tetraphosphate (AP4) does not induce the aggregation of platelets but inhibits the aggregation and release reaction in platelet-rich plasma promoted by ADP. The inhibitory action of AP4 on the aggregation by ADP is compared with that of AMP and ATP. The data presented suggest a competitive manner of inhibition of the ADP-induced aggregation by AP4.
摘要
与之前的报道相反，高度纯化的四磷酸腺苷（AP4）不会诱导血小板聚集，反而会抑制由二磷酸腺苷（ADP）促进的富血小板血浆中的聚集和释放反应。将AP4对ADP诱导的聚集的抑制作用与一磷酸腺苷（AMP）和三磷酸腺苷（ATP）的抑制作用进行了比较。所呈现的数据表明AP4对ADP诱导的聚集具有竞争性抑制方式。
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