Brewster W R, DiSaia P J, Monk B J, Ziogas A, Yamada S D, Anton-Culver H
Division of Gynecologic Oncology, University of California Irvine Medical Center, California, USA.
Am J Obstet Gynecol. 1999 Jun;180(6 Pt 1):1464-7. doi: 10.1016/s0002-9378(99)70038-4.
Our goal was to use population-based data to determine the difference in 5-year survival in women diagnosed with cervical cancer between those aged 18-34 years and those aged 40-60 years.
The SEER (Surveillance, Epidemiology, and End Results) public-use database, 1973-1994, was used for this investigation. Only subjects with cervical carcinoma diagnosed between 1988 and 1990 were included. Subjects were stratified on age at diagnosis (<35 years or 40-60 years), clinical stage, histologic type, race-ethnicity, and grade.
Two thousand cases of invasive cervical cancer were identified. The younger subgroup of patients was diagnosed with earlier-stage disease more frequently than the older group (P =.0001). When adjustments were made for non-cervical cancer causes of death, there was no difference in 5-year survival between the 2 cohorts. African American women had a poorer 5-year survival (P =.02)
There was no overall difference in survival between the 2 cohorts when appropriate adjustments were made for cause of death and for stage, histologic type, and grade of disease.
我们的目标是利用基于人群的数据，确定18至34岁与40至60岁被诊断为宫颈癌的女性在5年生存率上的差异。
本研究使用了1973 - 1994年的SEER（监测、流行病学和最终结果）公共使用数据库。仅纳入1988年至1990年间被诊断为宫颈癌的受试者。受试者按诊断时的年龄（<35岁或40 - 60岁）、临床分期、组织学类型、种族和分级进行分层。
共确定了2000例浸润性宫颈癌病例。较年轻的患者亚组比年长组更频繁地被诊断为早期疾病（P = 0.0001）。在对非宫颈癌死亡原因进行调整后，两个队列的5年生存率没有差异。非裔美国女性的5年生存率较差（P = 0.02）
在对死亡原因以及疾病的分期、组织学类型和分级进行适当调整后，两个队列的生存率没有总体差异。
