Reichert D, Liebaldt G, Henschler D
Arch Toxicol. 1976 Dec 23;37(1):23-38. doi: 10.1007/BF00353352.
In inhalation tests involving lethal as well as sublethal doses of dias examined in rabbits by means ofhistologic and neurofunctional methods. Histologic examination revealed chromatolysis, disintegration of Nissl bodies, and cell shrinkage in proportion to the doses employed in the nuclei of the unpaired brain stem, in the sensory cortical regions and especially in the sensory cranial nerve nuclei. The sensory trigeminal nucleus was involved most severely, followed in decreasing intensity 0y the facial and oculomotor nerves and the motor trigeminal nucleus; the least changes were observed in the acoustic nerve. By testing the protopathic sensitivity of the facial skin it was possible for the first time to produce evidence of a sensory loss in the distribution of the trigeminal nerve by animal experimentation. The neuropathological and functional deficits observed may explain the cranial nerve lesions in human DCA intoxication; however, these lesions seem to be less distinct in experimental animals.
在通过组织学和神经功能方法对兔子进行的涉及致死剂量和亚致死剂量二氯乙酸的吸入试验中。组织学检查显示，在不成对脑干核、感觉皮质区域，尤其是感觉性颅神经核中，出现了染色质溶解、尼氏体解体以及细胞萎缩，且与所使用的剂量成比例。感觉三叉神经核受累最为严重，其次是强度逐渐降低的面神经、动眼神经和运动三叉神经核；听神经的变化最小。通过测试面部皮肤的原发性敏感性，首次通过动物实验证实了三叉神经分布区域存在感觉丧失。观察到的神经病理学和功能缺陷可能解释了人类二氯乙酸中毒时的颅神经损伤；然而，这些损伤在实验动物中似乎不太明显。
