Boonchai W, Laohasrisakul R, Manonukul J, Kulthanan K
Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Int J Dermatol. 1999 May;38(5):348-50. doi: 10.1046/j.1365-4362.1999.00694.x.
Previous reports have shown the correlation between certain skin disorders and immune status in human immunodeficiency virus (HIV) infected patients. Pruritic papular eruption (PPE) is the most common cutaneous manifestation in HIV infected patients. The purpose of this study is to define the relationship between the presentation of PPE and the immune status in HIV infection, as measured by the T-cell subset, and to establish the usefulness of this common eruption as a predictor of CD4 count.
In this cross-sectional study, 20 HIV-positive patients with characteristics of PPE were studied. Clinical data, skin biopsy, and immune status, evaluated by measuring CD4, CD8, and CD4/CD8, were investigated.
Seventy-five per cent of patients already had antecedent skin disorders, so PPE is not a leading symptom in HIV infected patients; 81.25% of PPE patients had an advanced degree of immunosuppression with a CD4 count below 100/mm3 and 75% below 50/mm3.
PPE can be regarded as a cutaneous marker of advanced HIV infection.
既往报道显示，人类免疫缺陷病毒（HIV）感染患者的某些皮肤疾病与免疫状态之间存在相关性。瘙痒性丘疹性皮疹（PPE）是HIV感染患者最常见的皮肤表现。本研究的目的是确定PPE的表现与HIV感染免疫状态（通过T细胞亚群测量）之间的关系，并确定这种常见皮疹作为CD4细胞计数预测指标的有用性。
在这项横断面研究中，对20例具有PPE特征的HIV阳性患者进行了研究。调查了临床数据、皮肤活检以及通过测量CD4、CD8和CD4/CD8评估的免疫状态。
75%的患者已有既往皮肤疾病，因此PPE并非HIV感染患者的主要症状；81.25%的PPE患者存在晚期免疫抑制，CD4细胞计数低于100/mm³，75%低于50/mm³。
PPE可被视为晚期HIV感染的皮肤标志物。
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