De Martino S P, Errington F, Ashworth A, Jowett T, Austin C A
School of Biochemistry and Genetics, Catherine Cookson Building, Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK.
Dev Genes Evol. 1999 Jun;209(6):357-62. doi: 10.1007/s004270050264.
The Sox family of proteins is thought to act to regulate gene expression in a wide variety of developmental processes. Here we describe the cloning of sox30, a novel sox gene from the zebrafish (Danio rerio). In situ hybridization shows that sox30 is expressed in a restricted manner at the boundary between the midbrain and hindbrain during nervous system development. This expression pattern is in direct contrast to that of most other neuronally expressed Sox genes which are expressed throughout the nervous system.
Sox蛋白家族被认为在多种发育过程中发挥调节基因表达的作用。在此,我们描述了斑马鱼(Danio rerio)中一个新的Sox基因sox30的克隆。原位杂交显示,在神经系统发育过程中,sox30在中脑和后脑之间的边界处以受限的方式表达。这种表达模式与大多数其他在整个神经系统中表达的神经元表达的Sox基因的表达模式形成直接对比。