斑马鱼sox11A、sox11B和sox21的表达模式。
Expression patterns of zebrafish sox11A, sox11B and sox21.
作者信息
Rimini R, Beltrame M, Argenton F, Szymczak D, Cotelli F, Bianchi M E
机构信息
Dipartimento di Genetica e di Biologia dei Microrganismi, Università di Milano, via Celoria 26, 20133, Milan, Italy.
出版信息
Mech Dev. 1999 Dec;89(1-2):167-71. doi: 10.1016/s0925-4773(99)00199-9.
We have cloned three sox genes in zebrafish (Danio rerio), one related to human and chicken SOX21, and two related to mammalian and chicken Sox-11. Zebrafish sox21, sox11A and sox11B transcripts are accumulated in the egg, are present in all cells until gastrulation and become restricted later to the developing central nervous system (CNS); expression in adults is undetectable. sox21 is expressed in the forebrain, midbrain and hindbrain, but maximally at the midbrain-hindbrain junction; sox11A,B have a widespread and dynamic expression in the CNS, but in contrast to sox21 are absent at the midbrain-hindbrain boundary.
我们在斑马鱼（Danio rerio）中克隆了三个sox基因，一个与人类和鸡的SOX21相关，另外两个与哺乳动物和鸡的Sox-11相关。斑马鱼的sox21、sox11A和sox11B转录本在卵中积累，在原肠胚形成前存在于所有细胞中，随后局限于发育中的中枢神经系统（CNS）；成体中未检测到表达。sox21在前脑、中脑和后脑表达，但在中脑-后脑交界处表达量最高；sox11A、B在中枢神经系统中具有广泛且动态的表达，但与sox21不同，在中脑-后脑边界处不存在表达。
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