Lindholm J, Fabricius-Bjerre N, Bahnsen M, Boiesen P, Hagen C, Christensen T
Eur J Clin Invest. 1978 Oct;8(5):273-6. doi: 10.1111/j.1365-2362.1978.tb00841.x.
Thirty men with chronic alcoholism were studied. Biopsies of the liver and testis were performed in all. Serum concentrations of total and non-protein bound (free) testosterone and oestradiol, dihydrotestosterone and sex-hormone binding globulin (SHBG) were determined. Testosterone and dihydrotestosterone concentrations were normal in most patients, whereas oestradiol and free oestradiol were above normal in approximately 50% of the patients. None of the hormones measured differed significantly between patients with and without cirrhosis. SGBG was significantly higher in men with severely reduced spermatogenesis compared to those with intact germinal epithelium, but there was no difference between men with and without cirrhosis. No relation could be demonstrated between clinical signs of hypogonadism and any of the hormones measured. The results support the view that hormonal and sexual disturbances may occur in chronic alcoholism independent of the presence of liver disease.
对30名慢性酒精中毒男性进行了研究。所有人都进行了肝脏和睾丸活检。测定了血清总睾酮、非蛋白结合（游离）睾酮、雌二醇、双氢睾酮和性激素结合球蛋白（SHBG）的浓度。大多数患者的睾酮和双氢睾酮浓度正常，而约50%的患者雌二醇和游离雌二醇高于正常水平。在有肝硬化和无肝硬化的患者之间，所测激素均无显著差异。与生殖上皮完整的男性相比，精子发生严重减少的男性SGBG显著更高，但有肝硬化和无肝硬化的男性之间没有差异。性腺功能减退的临床体征与所测任何激素之间均无关联。这些结果支持这样一种观点，即慢性酒精中毒可能会出现激素和性功能障碍，而与肝脏疾病的存在无关。
