Incandela S, Aragona F, Di Marco G
Istituto di Clinica Otorinolaringoiatrica, Policlinico P. Giaccone, Universita di Palermo, Italy.
Rev Laryngol Otol Rhinol (Bord). 1999;120(1):35-8.
Adenocarcinoma "not otherwise specified" of the larynx appears to be extremely rare. We report a case of adenocarcinoma "NOS" arising in the larynx of a 72 year-old white man. The neoplasia was ALCIAN and PAS negative. Immuno-histochemical studies revealed negative immunoreactivity from NSE, chromogranins and S100; cytokeratin was positive. Electron microscopy revealed electrodense granules of varying sizes, but with no obvious central core surrounded by a limiting membrane. The patient underwent a total laryngectomy and functional neck dissection, with mandibular extension. And he is free of tumor after 4 years postoperatively.
喉“未另行特指”的腺癌似乎极为罕见。我们报告一例发生于一名72岁白人男性喉部的“未另行分类”腺癌病例。该肿瘤阿利新蓝染色及过碘酸雪夫染色均为阴性。免疫组织化学研究显示神经元特异性烯醇化酶、嗜铬粒蛋白和S100免疫反应均为阴性；细胞角蛋白呈阳性。电子显微镜检查发现有大小各异的电子致密颗粒，但没有明显的中央核心且无界膜包绕。该患者接受了全喉切除术及功能性颈清扫术，并扩大至下颌。术后4年他未出现肿瘤复发。
