Eisner M, Shalev E, Amrein R, Ferrat E
Arzneimittelforschung. 1976;26(10):1842-9.
The effect of 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotinic acid hydrochloride (difenoxin, R 15 403), a new antidiarrhoic agent, was studied in vivo in rats with an isolated colonic loop. Difenoxin had no effect on transport or absorption of fluid during perfusion experiments. When given i.p. it inhibited the motility of the coecum but not that of the colon. Difenoxin has apparently no effect on normal rat colon, although an effect may have been masked by the wide variation of parameters measured under identical conditions.
新型止泻药1-(3-氰基-3,3-二苯基丙基)-4-苯基异哌啶盐酸盐（地芬诺辛，R 15 403）的作用，通过大鼠离体结肠袢在体内进行了研究。在灌注实验中，地芬诺辛对液体的转运或吸收没有影响。腹腔注射时，它可抑制盲肠的运动，但对结肠运动无影响。地芬诺辛对正常大鼠结肠显然没有作用，尽管在相同条件下测量的参数变化很大，可能掩盖了其作用效果。
