[关于地芬诺辛（R15403）的作用方式。第一部分：对离体肠平滑肌的研究（作者译）]
[On the mode of action of difenoxine (R15403). Part 1: Studies on isolated intestinal smooth muscle (author's transl)].
作者信息
Eisner M, Ferrat E
出版信息
Arzneimittelforschung. 1976;26(9):1642-4.
PMID:1036692
Abstract
1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-isonicotinic acid hydrochloride (difenoxine, R 15 403) in vitro acts directly on gastrointestinal smooth muscle. It inhibits spontaneous contractions, it antagonizes the histamin-induced contractions and partially inhibits acetylcholine. Compared with pethidine difenoxine appears 50 times more powerful.
摘要
1-（3-氰基-3,3-二苯基丙基）-4-苯基异烟酸盐酸盐（地芬诺辛，R 15 403）在体外直接作用于胃肠道平滑肌。它抑制自发收缩，拮抗组胺诱导的收缩，并部分抑制乙酰胆碱。与哌替啶相比，地芬诺辛的效力要强50倍。
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