Boselli P, Gervasi G B, Scrollini F
Arzneimittelforschung. 1976;26(11):2038-9.
The serum kinetics and urinary metabolism of an a-sympathomimetic amine 1-(3,5-dimethoxy-4-hydroxyphenyl)-2-monomethyl-amino-ethanol (dimethophrine) were studied. For serum kinetics, seven groups of 6 rats were sacrificed at 0.083, 1, 2, 2, 4, 6 and 12 H, respectively, after tail administration of dimethophrine-7-3H. Only 1 group of 6 rats was placed into metabolism cages to collect urine at 12-h intervals during the 72 h after dimethophrine-7-3H administration as above. The metabolic identification was made by thin-layer chromatography (TLC) and the radiochromatograms were obtained by the "scraping" method. This work shows dimethophrine to be unchanged in the urine of rat.
研究了一种α-拟交感神经胺1-(3,5-二甲氧基-4-羟基苯基)-2-单甲基氨基乙醇（地美沙芬）的血清动力学和尿代谢情况。对于血清动力学，在经尾静脉注射7-³H标记的地美沙芬后，分别于0.083、1、2、2、4、6和12小时处死7组，每组6只大鼠。如上述那样，在注射7-³H标记的地美沙芬后的72小时内，仅将1组6只大鼠放入代谢笼中，每隔12小时收集尿液。通过薄层色谱法（TLC）进行代谢鉴定，并采用“刮取”法获得放射色谱图。这项研究表明，地美沙芬在大鼠尿液中未发生变化。
