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[一种测定生物材料中药物的新荧光法(作者译)]

[A new fluorometric method for the determination of drugs in biological material (author's transl)].

作者信息

Hajdú P, Damm D

出版信息

Arzneimittelforschung. 1976;26(12):2141-5.

PMID:1037263
Abstract

A description is given of a new method for fluorometric determination of drugs in biological material. The assay is based on photochemical transformation of non-fluorescent compounds in fluorophors by short-wave UV light. The pharmacokinetics of the 2-[4-(4'-chlorophenoxy)-phenoxy]-propionic acid (HCG 004) serves as an example to demonstrate the usefulness of this method; reference is also made to analogously successful studies of other drugs.

摘要

本文描述了一种用于荧光测定生物材料中药物的新方法。该测定基于短波紫外光将非荧光化合物光化学转化为荧光团。以2-[4-(4'-氯苯氧基)-苯氧基]-丙酸(HCG 004)的药代动力学为例,证明了该方法的实用性;同时也提及了其他药物类似的成功研究。

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