Kool J, de Keizer R J, Siegert C E
Department of Ophthalmology, Leiden University Medical Centre, The Netherlands.
Am J Ophthalmol. 1999 Jun;127(6):738-9. doi: 10.1016/s0002-9394(98)00425-5.
To describe the follow-up of patients with orbital Wegener granulomatosis after antithymocyte globulin treatment.
Patients with ocular/orbital Wegener granulomatosis refractory to standard treatment were selected for immunotherapy with rabbit antithymocyte globulin intravenously. The specific ocular/orbital symptoms were monitored in patients with a vision-threatening form of Wegener granulomatosis or a life-threatening form with ocular symptoms.
One patient had a complete remission, two patients had remissions but still needed additional treatment, and one patient remained refractory.
In selected patients, antithymocyte globulin immunotherapy may present an alternative when vision or life is threatened by orbital Wegener granulomatosis.
描述抗胸腺细胞球蛋白治疗眼眶韦格纳肉芽肿患者的随访情况。
选择对标准治疗无效的眼/眼眶韦格纳肉芽肿患者，采用兔抗胸腺细胞球蛋白进行静脉免疫治疗。对患有视力威胁型韦格纳肉芽肿或伴有眼部症状的生命威胁型患者的特定眼/眼眶症状进行监测。
1例患者完全缓解，2例患者缓解但仍需额外治疗，1例患者仍难治。
对于选定的患者，当眼眶韦格纳肉芽肿威胁视力或生命时，抗胸腺细胞球蛋白免疫治疗可能是一种替代方案。
