[阳离子铁蛋白对肾小球基底膜及系膜区通透性的影响]
[The effect of cationic ferritin to the permeability of renal glomerular basement membrane and the mesangial area].
作者信息
Li L, Shigeru S, Kaoru A
机构信息
Department of Urology, 2nd Hospital, Dalian.
出版信息
Zhonghua Bing Li Xue Za Zhi. 1997 Oct;26(5):301-2.
OBJECTIVE
To study the effect of cationic ferritin (CF) to the permeability of the glomerular basement membrane (GBM) and the mesangial area.
METHODS
Single dose of CF 50mg/kg/rat given intravenously. Samples taken from the kidney were studied under electronic microscope by polyethylenimine (PEI) staining.
RESULTS
The number of PEI granules in GBM changed obviously while those in the mesangial matrix (MM) remained unchanged.
CONCLUSION
The negative charge in GBM serves as a charge barrier relating with proteinuria and the MM serves as the lymphatic pathway with no connection with proteinuria.
目的
研究阳离子铁蛋白（CF）对肾小球基底膜（GBM）通透性及系膜区的影响。
方法
以50mg/kg/大鼠的剂量静脉注射CF。对取自肾脏的样本进行聚乙烯亚胺（PEI）染色后在电子显微镜下观察。
结果
GBM中PEI颗粒数量明显改变，而系膜基质（MM）中的颗粒数量保持不变。
结论
GBM中的负电荷作为与蛋白尿相关的电荷屏障，而MM作为淋巴通路，与蛋白尿无关。
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