Kriz W, Elger M, Lemley K V, Sakai T
Institut für Anatomie und Zellbiologie, Universität Heidelberg, BRD.
Am J Nephrol. 1990;10 Suppl 1:4-13. doi: 10.1159/000168186.
Glomerular capillaries are perfused at a high hydraulic pressure. Since the capillary mesangium interface presents no morphologically apparent pressure barrier, it is suggested that the hydraulic pressure in the mesangium may also be high. This paper analyzes the structures in the glomerular tuft that are capable of counteracting the distending forces exerted on the tuft by the high hydraulic pressure in its center. The skeletal element of the glomerular tuft is the glomerular basement membrane (GBM). The combination of the GBM with the contractile apparatus of mesangial cells represents the main system stabilizing the glomerular tuft. The mesangial cell-GBM connections counteracting the expansion of glomerular capillaries appear less susceptible to injury than those counteracting mesangial expansion.
肾小球毛细血管以较高的液压灌注。由于毛细血管系膜界面不存在形态学上明显的压力屏障，因此有人认为系膜中的液压也可能较高。本文分析了肾小球丛中能够抵消其中心高液压施加在丛上的扩张力的结构。肾小球丛的骨架成分是肾小球基底膜（GBM）。GBM与系膜细胞的收缩装置相结合是稳定肾小球丛的主要系统。抵消肾小球毛细血管扩张的系膜细胞-GBM连接似乎比抵消系膜扩张的连接更不易受到损伤。
