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[288例恶性肝门部梗阻患者的内镜下胆道引流评估]

[The evaluation of endoscopic biliary drainage for 288 patients with malignant hilar obstruction].

作者信息

Hu B, Zhou D, Gong B

机构信息

Second Military Medical University, Shanghai Oriental Hepatobiliary Surgery Hospital.

出版信息

Zhonghua Wai Ke Za Zhi. 1997 Feb;35(2):73-6.

Abstract

Hilar tumors are extremely difficult to manage with a considerably lower resection rate. We performed endoscopic biliary drainage for 288 patients with hilar tumors (Klatskin tumor 184, gallbladder carcinoma 23, HCC 47 and other metastases 34) in the past 3 years. 162 patients underwent endoscopic nasobiliary drainage, 80 plastic biliary stenting, and 46 expandable metal stent implantation. 4 patients were given double stents insertion simultaneously, 43.1% of patients received good drainage with the total effective rate of 67.0%, but postprocedure cholangitis took place in 13.8% of patients within one month and 3 died of cholangitis and sepsis. In the long-term follow-up patients without surgical treatment, the median sruvival was 5.3 months. The outcome was closely related to Bismuth types, and jaundice could be relieved if more than about 40% of the liver was drained. The double stents for the left and right intrahepatic duct in the meantime could enlarge drainage area and improve the theraputic effectiveness. To get highest benefit, the 3 endoscopic biliary drainage methods should be choosen properly and exchanged flexibly. We conclude that endoscopic biliary drainage is a safe and useful management for the hilar tumor and should be the treatment of choice for palliating jaundice in the inoperable patients.

摘要

肝门部肿瘤极难处理,切除率相当低。在过去3年中,我们对288例肝门部肿瘤患者(184例肝门部胆管癌、23例胆囊癌、47例肝癌及34例其他转移瘤)进行了内镜下胆道引流。162例患者接受了内镜鼻胆管引流,80例进行了塑料胆管支架置入,46例进行了可扩张金属支架植入。4例患者同时置入了双支架,43.1%的患者引流良好,总有效率为67.0%,但13.8%的患者在术后1个月内发生胆管炎,3例死于胆管炎和败血症。在未接受手术治疗的长期随访患者中,中位生存期为5.3个月。结果与Bismuth分型密切相关,如果肝脏引流超过约40%,黄疸可得到缓解。同时对左右肝内胆管置入双支架可扩大引流面积,提高治疗效果。为获得最大益处,应正确选择并灵活更换3种内镜下胆道引流方法。我们得出结论,内镜下胆道引流是肝门部肿瘤一种安全有效的治疗方法,应成为无法手术患者缓解黄疸的首选治疗方法。

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