Liu H, Zhang K, Wang Z
Department of Neurosurgery, Xinqiao Hospital, 3rd Military Medical College, Chongqing.
Zhonghua Wai Ke Za Zhi. 1997 Jan;35(1):22-5.
We transplanted the fresh and Iloprost or saline preserved (3 hours) embryonic rat cortical brain tissue into the rats in which the motor cortex had been injured and compared the neurobehavioral and morphological changes. The neurobehavior of the transplanted groups was more significantly improved than that in the injured, untransplanted group. The neurobehavior of the animals of the fresh tissue group and Iloprost preserved group recovered to the preinjurylevel. The survival rate of the Iloprost preserved grafts was 90%, which was higher than that of the saline preserved grafts (P < 0.05). In comparison with the fresh grafts, however, there was no significant difference (P > 0.05). In addition, the growth volume of the Iloprost preserved grafts was more markedly increased than that of the fresh grafts (P < 0.01). We conclude that injured brain may be repaired effectively by transplantation of fetal brain cortex. The Iloprost solution not only maintains of vitality the grafts, but also promotes its survival and growth in the host brain.
我们将新鲜的、经伊洛前列素或生理盐水保存（3小时）的胚胎大鼠皮质脑组织移植到运动皮质受损的大鼠体内，并比较其神经行为和形态学变化。移植组的神经行为改善程度比受伤未移植组更为显著。新鲜组织组和伊洛前列素保存组动物的神经行为恢复到损伤前水平。伊洛前列素保存移植物的存活率为90%，高于生理盐水保存移植物（P<0.05）。然而，与新鲜移植物相比，差异无统计学意义（P>0.05）。此外，伊洛前列素保存移植物的生长体积比新鲜移植物显著增加（P<0.01）。我们得出结论，胎儿脑皮质移植可有效修复受损脑。伊洛前列素溶液不仅能维持移植物的活力，还能促进其在宿主脑中的存活和生长。
