[Interaction of octapeptide of cholecystokinin, vasoactive intestinal peptide and substance P on dynamics of biliary system and cardiovascular system].

We tested in vivo: (a) the effect of an i.v. infusion of cholecystokinin octapeptide, vasoactive intestinal peptide or substance P on dynamics of biliary system and cardiovascular system, (b) the relation of dynamics of biliary system and cardiovascular system. In 91 anesthetized guinea pigs, left ventricle motility of heart, sphincter of Oddi motility and common bile duct pressure were monitored during the intravenous administration of cholecystokinin octapeptide (CCK-OP), vasoactive intestinal peptide (VIP), substance P (SP) and combination of CCK-OP and VIP. Intravenous CCK-OP increased fasting Oddis sphincter motility index, decreased the basal pressure in sphincter of Oddi, increased common bile duct pressure, and decreased the left ventricle of heart motility. VIP alone showed no significant effect on biliary system and cardiovascular system, but in conjunction with CCK-OP it produced inhibition on the effects of CCK-OP on both sides. Exogenous SP acted like CCK-OP on both biliary system and cardiovascular system, but it was less potent. We conclude that it may be an important interaction between dynamics of biliary system and cardiovascular system; and gastrointestinal peptide plays an important role in this interaction in guinea pigs.