Dong Maosheng, Sonoda Yukio, Kawamoto Masahiko, Konomi Hiroyuki, Kobayashi Kiichiro, Yamaguchi Koji, Tanaka Masao
Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
J Gastroenterol. 2005 Apr;40(4):389-95. doi: 10.1007/s00535-004-1557-9.
We investigated the role of the duodenum in the sphincter of Oddi response to cholecystokinin-octapeptide (CCK-OP), using conscious dogs.
In controls, a cannula was inserted into the duodenum opposite the papilla for retrograde manometry. In the duodenectomy group, the entire duodenum was resected, while preserving the papilla, which was implanted into the jejunum, and the cannula was placed. Sphincter motility was recorded after bolus injections of 20 and 100 ng/kg of CCK-OP.
CCK-OP at 20 ng/kg produced sphincter relaxation followed by contraction in the controls, but produced no changes after duodenectomy. CCK-OP at 100 ng/kg caused strong contractions followed by relaxation in the controls, but caused only contractions after duodenectomy.
(1) Relaxation and delayed contraction of the sphincter induced by 20 ng/kg of CCK-OP require the presence of the duodenum; (2) early contractions of the sphincter induced by 100 ng/kg of CCK-OP do not require the duodenum; (3) the duodenum plays an important role in the actions of CCK-OP on sphincter motility.
我们使用清醒犬研究十二指肠在Oddi括约肌对胆囊收缩素八肽（CCK-OP）反应中的作用。
在对照组中，将套管插入乳头对面的十二指肠进行逆行测压。在十二指肠切除术组中，切除整个十二指肠，同时保留乳头，将其植入空肠，并放置套管。在推注20和100 ng/kg的CCK-OP后记录括约肌运动。
20 ng/kg的CCK-OP在对照组中引起括约肌松弛，随后收缩，但在十二指肠切除术后无变化。100 ng/kg的CCK-OP在对照组中引起强烈收缩，随后松弛，但在十二指肠切除术后仅引起收缩。
（1）20 ng/kg的CCK-OP诱导的括约肌松弛和延迟收缩需要十二指肠的存在；（2）100 ng/kg的CCK-OP诱导的括约肌早期收缩不需要十二指肠；（3）十二指肠在CCK-OP对括约肌运动的作用中起重要作用。
