一种通过对链霉菌属发酵液进行酸处理产生的新型细胞毒性2H-吡喃化合物。

A new cytotoxic 2H-pyran compound produced by acid treatment of the fermentation broth of Streptomyces sp.

作者信息

Nosaka C, Kunimoto S, Masuda T, Ohsono M, Iinuma H, Tsuchida T, Hamada M, Takeuchi T

机构信息

Institute of Microbial Chemistry, Tokyo, Japan.

出版信息

Biol Pharm Bull. 1999 May;22(5):546-8. doi: 10.1248/bpb.22.546.

DOI:10.1248/bpb.22.546

PMID:10375181

Abstract

A new cytotoxic substance was isolated following acid treatment of fermented broth of a Streptomyces strain numbered MJ915-WF12. The structure was elucidated by spectroscopic analyses to be 5-dihydro-4-formyl-6-hydroxy-2-hydroxymethyl-6-methyl-2H-pyran. It was thought to be generated by dehydration and ring reformation of the precursor material in cultured broth by acid.

摘要

对编号为MJ915-WF12的链霉菌菌株发酵液进行酸处理后，分离出一种新的细胞毒性物质。通过光谱分析确定其结构为5-二氢-4-甲酰基-6-羟基-2-羟甲基-6-甲基-2H-吡喃。据认为它是由培养液中的前体物质经酸脱水和环化重排生成的。