Shu Y Z, Ye Q, Kolb J M, Huang S, Veitch J A, Lowe S E, Manly S P
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.
J Nat Prod. 1997 May;60(5):529-32. doi: 10.1021/np970054v.
Bripiodionen (1), a new natural product, was isolated from Streptomyces sp. WC76599 during the screening of microbial fermentation extracts for their ability to inhibit human cytomegalovirus protease. The structure of 1 was elucidated by spectroscopic methods. Compound 1 displayed inhibitory activity against human cytomegalovirus protease with an IC50 value of 30 microM.
布里皮奥地宁（1）是一种新的天然产物，在筛选微生物发酵提取物抑制人巨细胞病毒蛋白酶能力的过程中，从链霉菌属WC76599中分离得到。通过光谱方法阐明了1的结构。化合物1对人巨细胞病毒蛋白酶具有抑制活性，IC50值为30微摩尔。
