Aloisio F, Giannoni M F, Montesani C, Pizzirani F
Chir Ital. 1976 Dec;28(6):846-53.
After a short analysis of the pathogenetic causes which can lead to paralytic ileus and the drugs at present available for treatment of this serious morbid form, the paper reports results obtained with Ceruletide, a decapeptide which has proved active on intestinal peristalsis in experimental and clinical trials. The results of this study, carried out on 20 patients subjected to surgical operation on the abdomen, treated with Ceruletide by intramuscular route 24-48 hours after the operation, showed that this drug is capable of leading to a quick recovery of intestinal motor activity without causing the patient unpleasant effects for the patient. The practical utility of Ceruletide is evident since by leading to earlier canalisation of the intestine it also allows the venous hydro-electric delivery to be reduced, nasogastric aspiration to be eliminated early and hence the postoperative course to be made more acceptable to the patient.
在简要分析了可能导致麻痹性肠梗阻的发病原因以及目前可用于治疗这种严重病症的药物后，本文报告了用赛鲁肽（一种十肽）所取得的结果，该十肽在实验和临床试验中已证明对肠道蠕动有活性。这项研究对20名接受腹部手术的患者进行，术后24至48小时通过肌肉注射途径用赛鲁肽进行治疗，结果表明该药物能够使肠道运动活动迅速恢复，且不会给患者带来不适。赛鲁肽的实际效用是明显的，因为它能使肠道更早地恢复通畅，还能减少静脉水电输送量，尽早消除鼻胃管抽吸，从而使患者术后过程更易接受。
