Meyer J, Sulkowski U, Preusser P
Klinik und Poliklinik für Allgemeine Chirurgie, Westfälische Wilhelms-Universität, Münster.
Med Klin (Munich). 1991 Oct 15;86(10):515-7.
In a pilot-study 25 patients presenting with a paralytic ileus due to diffuse intraabdominal metastases were treated with motilin. There were 16 male (64%) and nine female (36%) patients. Gastric cancer was the most frequent cause (40%), followed by pancreatic (36%), and colorectal (20%) cancer. 36% had received a postoperative chemotherapy before commencing the motilin-scheme. In 92% motilin therapy was started within 48 hours after the diagnosis of paralytic ileus. There were no serious side-effects of motilin therapy. In approximately 80% the pretherapeutic state was improved. Thus, it seems worthwhile to investigate the influence of motilin on paralytic ileus in incurable cancer patients in a prospective controlled trial.
在一项试点研究中，25例因弥漫性腹腔内转移而出现麻痹性肠梗阻的患者接受了胃动素治疗。其中男性16例（64%），女性9例（36%）。胃癌是最常见的病因（40%），其次是胰腺癌（36%）和结直肠癌（20%）。36%的患者在开始胃动素治疗方案前接受过术后化疗。92%的患者在诊断为麻痹性肠梗阻后48小时内开始胃动素治疗。胃动素治疗没有严重的副作用。约80%的患者治疗前状态得到改善。因此，在前瞻性对照试验中研究胃动素对无法治愈的癌症患者麻痹性肠梗阻的影响似乎是值得的。
