细胞毒性T淋巴细胞相关抗原4与T细胞活化

CTLA-4 and T cell activation.

作者信息

Oosterwegel M A, Greenwald R J, Mandelbrot D A, Lorsbach R B, Sharpe A H

机构信息

Immunology Research Division, Department of Pathology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Curr Opin Immunol. 1999 Jun;11(3):294-300. doi: 10.1016/s0952-7915(99)80047-8.

DOI:10.1016/s0952-7915(99)80047-8

PMID:10375557

Abstract

The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD28. Recent work has also revealed a role for CTLA-4 in regulating Th1/Th2 differentiation. Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases.

摘要

过去一年里，我们对细胞毒性T淋巴细胞相关抗原4（CTLA-4）在调节T细胞活化及耐受性方面作用的理解取得了重大进展。近期研究表明，CTLA-4不仅可平衡CD28信号，还能独立于CD28抑制T细胞应答。近期研究还揭示了CTLA-4在调节Th1/Th2分化中的作用。在自身免疫动物模型中对CTLA-4进行操控的研究表明，CTLA-4对自身免疫性疾病的起始和进展均有调节作用。