Murphy N P, Lee Y, Maidment N T
Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024, USA.
Brain Res. 1999 Jun 19;832(1-2):168-70. doi: 10.1016/s0006-8993(99)01425-0.
Orphanin FQ/nociceptin (OFQ/N) suppresses the activity of the dopaminergic mesolimbic reward pathway yet reportedly fails to produce conditioned place aversion or preference. The present study sought to determine if this peptide could attenuate the development of morphine place preference. Male rats were administered OFQ/N (3 to 30 nmol intracerebroventricularly) during the induction of morphine (3 mg/kg subcutaneously) place preference. Animals receiving 3 or 10 nmol (but not 30 nmol) OFQ/N showed significant reductions in the development of place preference to morphine.
孤啡肽/痛敏肽（OFQ/N）可抑制多巴胺能中脑边缘奖赏通路的活性，但据报道它不会产生条件性位置厌恶或偏好。本研究旨在确定该肽是否能减弱吗啡位置偏好的形成。在诱导吗啡（皮下注射3mg/kg）位置偏好的过程中，给雄性大鼠脑室内注射OFQ/N（3至30nmol）。接受3或10nmol（而非30nmol）OFQ/N的动物对吗啡的位置偏好形成显著降低。
