Devine D P, Reinscheid R K, Monsma F J, Civelli O, Akil H
Mental Health Research Institute, University of Michigan, Ann Arbor 48109-0720, USA.
Brain Res. 1996 Jul 15;727(1-2):225-9. doi: 10.1016/0006-8993(96)00476-3.
An unbiased conditioned place preference procedure was used to determine whether the newly-identified neuropeptide orphanin FQ produced motivational effects after intracerebroventricular microinjections. Microinjections of orphanin FQ (0.1-100 nmol) failed to produce conditioned place preference or aversion, but a pronounced motor impairment was observed during conditioning sessions with the two highest doses. Thus, it appears that orphanin FQ lacks motivational effects when administered at behaviourally active doses.
采用无偏倚条件性位置偏爱程序来确定新发现的神经肽孤啡肽在脑室内微量注射后是否产生动机效应。微量注射孤啡肽（0.1 - 100纳摩尔）未能产生条件性位置偏爱或厌恶，但在使用两个最高剂量进行条件反射训练期间观察到明显的运动障碍。因此，当以行为活性剂量给药时，孤啡肽似乎缺乏动机效应。
