Li A L, Shi Y D, Landsmann B, Schanowski-Bouvier P, Dikta G, Bauer U, Artmann G M
Department of Applied Cell Biophysics and Bioengineering, Aachen University of Applied Sciences, Jülich, Germany.
Zhongguo Yao Li Xue Bao. 1998 Sep;19(5):417-21.
To study the effects of Ginkgo biloba extract 761 (GbE) from the points of view of hemorheology for patients of peripheral arterial occlusive diseases (PAOD).
The treatment with GbE (240 mg.d-1, po) and the pain-free walking distance (PFWD) were carried out for 24 PAOD patients (12 nondiabetic, ND and 12 diabetic, D) over 48 wk. The parameters erythrocyte stiffness (ES) and relaxation time (RT), the blood plasma viscosity (eta), the plasma fibrinogen concentration (Cf) and the blood sedimentation rate (BSR), the PFWD, and maximal walking distance (MWD) were determined at 6 wk before treatment (-6), at the beginning of the treatment (0), and after 6, 11, 16, and 48 wk of treatment.
At wk -6, ES and RT of both the ND- and D-group were not significantly different from a healthy control group. At wk 0, stiffness and RT were significantly higher than healthy control, and the mean PFWD was only 111 m. The eta value was significantly elevated and Cf and BSR were enhanced. Throughout 11 wk of treatment ES, RT, eta, and Cf decreased gradually and PFWD improved. Between 16 and 48 wk, ES, and RT were no longer significantly different from the controls, whereas eta and Cf decreased gradually but remained higher than normal, BSR decreased, and the PFWD improved by a factor of 3.8 times (D) and 3.3 times (ND).
GbE gives therapeutic effects in PAOD patients.
从血液流变学角度研究银杏叶提取物761（GbE）对周围动脉闭塞性疾病（PAOD）患者的影响。
对24例PAOD患者（12例非糖尿病患者，ND；12例糖尿病患者，D）采用GbE（240mg·d-1，口服）治疗并进行无痛步行距离（PFWD）测定，疗程48周。在治疗前6周（-6）、治疗开始时（0）以及治疗6、11、16和48周后测定红细胞刚性（ES）和松弛时间（RT）、血浆黏度（η）、血浆纤维蛋白原浓度（Cf）和血沉率（BSR）、PFWD以及最大步行距离（MWD）。
在-6周时，ND组和D组的ES和RT与健康对照组相比无显著差异。在0周时，刚性和RT显著高于健康对照组，平均PFWD仅为111m。η值显著升高且Cf和BSR升高。在整个11周的治疗过程中，ES、RT、η和Cf逐渐降低，PFWD改善。在16至48周期间，ES和RT与对照组不再有显著差异，而η和Cf逐渐降低但仍高于正常水平，BSR降低，PFWD改善了3.8倍（D组）和3.3倍（ND组）。
GbE对PAOD患者有治疗作用。
