Pepe C, Rozza A, Veronesi G
Servizio di Chirurgia Vascolare, Casa di Cura Privata Polispecialistica, Villa Verde, Reggio Emilia.
Minerva Cardioangiol. 1999 Jun;47(6):223-30.
This study aimed to evaluate the influence of Ginkgo biloba extract with arginine and magnesium used for the treatment of trophic lesions in the lower limbs caused by both diabetic and non-diabetic microangiopathy.
A comparative study was carried out in 20 patients who were divided into two groups: 10 were treated with ASA plus Ginkgo biloba extract with arginine and magnesium and 10 with ASA plus conventional hemorheology. The observation time was extended to 6 months, taking into consideration patients with trophic lesions to the lower limbs suffering from diabetic and non-diabetic peripheral arterial occlusive disease. The evaluation was performed by clinical, ultrasonographic and perilesional video capillaroscopy monitoring. Ultrasonographic and video capillaroscopy instrumental methods were used because they provide a full picture of macro and microcirculatory conditions around lesions.
The study showed the undoubted efficacy of Ginkgo biloba extract with magnesium and arginine in relation to the following points: reduced healing times for the trophic lesion compared to the control group, improved painful symptoms, increased perilesional neoangiogenesis. No significant differences were observed from a Doppler ultrasonographic point of view or with regard to the claudication free interval.
Ginkgo biloba extract with arginine and magnesium can improve the dynamics of cutaneous trophism in lesions caused by diabetic and non-diabetic microangiopathy.
本研究旨在评估银杏叶提取物联合精氨酸和镁对糖尿病性和非糖尿病性微血管病变所致下肢营养性损害的治疗效果。
对20例患者进行了一项对比研究，将其分为两组：10例接受阿司匹林联合银杏叶提取物加精氨酸和镁的治疗，10例接受阿司匹林联合传统血液流变学治疗。考虑到患有糖尿病性和非糖尿病性外周动脉闭塞性疾病的下肢营养性损害患者，观察时间延长至6个月。通过临床、超声和病变周围视频毛细血管镜监测进行评估。使用超声和视频毛细血管镜检查仪器方法，因为它们能全面呈现病变周围的宏观和微循环状况。
该研究表明，银杏叶提取物联合镁和精氨酸在以下方面具有毋庸置疑的疗效：与对照组相比，营养性损害的愈合时间缩短，疼痛症状改善，病变周围新生血管生成增加。从多普勒超声角度或关于无跛行间隔时间方面未观察到显著差异。
银杏叶提取物联合精氨酸和镁可改善糖尿病性和非糖尿病性微血管病变所致病变中皮肤营养的动态变化。
